مشاريع التخرج - The effect of vitamin C on COVID-19
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  3.   The effect of vitamin C on COVID-19
عنوان المشروعThe effect of vitamin C on COVID-19
المشرف على المشروعم.م طيبة فارس هادي جاسم
العام الدراسي2020-2021
تقديم الطالبمحمد نهاد
و الطالبزينه حسن
ملخصSince the start of coronavirus disease 2019 “COVID-19” pandemic, multiple treatment regimens have been tried under the compassionate use indications. So far, no specifc antiviral drug has been proven to be efective, apart from remdesivir which showed promising results and has gained an emergency approval by Food and Drug Administration (FDA) to be used in the treatment of COVID-19 [1,2]. That is why supportive treatment, including supplementation of micronutrients such as vitamin C, has become a crucial part in management of COVID-19. It is noticed that serum and leukocyte levels of vitamin C is depleted during the acute stage of the infection [3,4] . Previous clinical trials found that supplementation with high dose of vitamin C decreased the severity and duration of respiratory viral infections[5]. Based on these fndings, vitamin C might be used in management of COVID-19 as it might improve the immunological response against the novel coronavirus (SARS-CoV-2). The pathological damage induced by SARS-CoV-2 infection is partially due to the direct viral virulence efect, but the main part is caused by massive host immune response and oxidative stress secondary to release of free radicals[5] . SARS-CoV-2 infection induces excessive release of proinfammatory cytokines, leading to cytokines storm, and increases production of reactive oxygen species which both cause signifcant lung damage which leads to subsequent development of adult respiratory distress syndrome (ARDS)[6,7] . ARDS can lead to further deterioration and development of septic shock which both are the common cause of intensive care unit (ICU) admission and mortality particularly in patients older than 60 years