م.د احمد سالم محمود
-
Antiepileptic Effect of Neuroaid® on Strychnine-Induced Convulsions in Mice
-
Abstract
NeuroAid II, a folk Chinese Medicine, is currently used in Asia for the treatment of stroke. An experimental study demonstrated that NeuroAid enables neuronal cells to be more resistant to glutamate toxicity. This research was constructed to evaluate the efficacy of NeuroAid in the prevention of epilepsy (EP). Forty healthy adult male mice were used and divided into four groups (10 mice/group): normal control group; positive control group; NeuroAid-treated group (10 mg/kg); topiramate-treated group (10 mg/kg). The treatment continued for 7 days, and on the last day, EP was induced using strychnine at a dose of 2 mg/kg via intraperitoneal (ip) administration. Seizure severity, latency to the seizure onset, the number of seizures, and the duration of each seizure episode were observed for one hour. The death and protection rates over the next twenty-four hours were recorded. Brain specimens from surviving animals were extracted and examined pathologically for quantification of glutamate receptor (GluR) gene expression in the isolated hippocampus employing real-time PCR analysis. Treatment with NeuroAid resulted in a significant reduction in seizure severity, prolonged the onset of seizures, decreased the number and duration of episodes, reduced brain insult, and decreased mortality rate. Reductions in the gene expression of GluRs in the hippocampus with minor histopathological changes were observed in the NeruoAid- and topiramate-treated groups. It is concluded that NeuroAid has a potential antiepileptic effect (EP) with the ability to prevent convulsion through its effect on the glutamate receptor. -
PDF
اخر البحوث المنشورة
-
Development and Validation Of A Dispersive Liquid-Liquid Microextraction Method For Metoclopramide Analysis In Pharmaceuticals And Biological Samples
-
أ.م.د. قتيبة ابراهيم خضر الزند2024
-
Unveiling a novel exopolysaccharide produced by pseudomonas alcaligenes med1 isolated from a chilean hot spring as biotechnological additive
-
م.م سرى جاسم محمد بريج2024
-
Preparation and Characterization of Atorvastatin Calcium Trihydrate-cyclodextrin Inclusion Complex
-
م.م بسمة مظفر هادي2022
-
Cross-allergic reactions between etoposide and penicillin in autologous bone marrow transplant patient
-
م.م علاء حسين عبدالله2022
-
Asthma prevalence among Iraqi children
-
م.م علاء حسين عبدالله2024